Endocrine Abstracts

Introduction: Despite advances in analytic and imaging techniques, the syndrome of ectopic ACTH secretion from a tumour resulting in Cushing’s syndrome continues to pose difficult diagnostic and therapeutic challenges. We report a patient with ectopic ACTH from a bronchial carcinoid tumour highlighting the unusual presentation and difficulties in management.Case description: A 23-year-old man with a past medical history of Cushing disease presented ...

Aim: To study the effect of testosterone replacement treatment in the aging male with T2DM.Material and methods: Twenty-six hypogonadal men with T2DM and late-onset hypogonadism between the age 50–65 years (55.00 (50.00; 58.00)) were treated with a 1% testosterone gel within 12 months.Results: Testosterone levels increased from 4.65 (2.70; 6.10) nmol/l at baseline to 13.65 (12.60; 15.20) nmol/l after 48 weeks of treatment (...

Background and aims: The aim of our study is to investigate the possible associations between leptin and fasting insulin and index HOMA-IR in patients with Metabolic Syndrome as Leptin is involved in regulation of body weight.Materials and methods: The study included 100 patients (32 m, 68 f) 25–65 years. They were divided into 2 groups matched by sex, age, weight, body mass index (BMI), waist-to-hip ratio (WHR). Research group included 56 patients ...

Myeloperoxidase (MPO), an enzyme of the innate immune system, exhibits pro-atherogenic effects and includes influence on oxidative damage to LDL- and HDL-cholesterol, and promotion of endothelial dysfunction.The aim: To investigate the disturbance of MPO in type 2 diabetic (T2D) patients depending on intensity of atherosclerosisMaterial and methods: We investigated 244 patients aged from 45 to 60 years (M±SD 54.0±4.63) in...

The aim was to evaluate the space of hyperhomocysteinemia presence with depression and diabetic nephropathy (DN) in diabetic mellitus type 1 (DMT1) patients.Materials and methods: it was examined 147 patients with DMT1 (57.1% of males, 42.9% - females) and duration of disease was 11.17 [9.07;12.26] years. Moderate age was 40.08 [30.44; 48.79] years. DN of 3–5 stages was diagnosed in 43 patients (29.3%). To provide analysis it used blood serum creati...

Rationality: T2DM is a component of the metabolic syndrome, the occurrence of overweight, arterial hypertension (AH), and dyslipidemia in T1DM is variable according to the literature.Objective: Study of the occurrence of overweight, AH and dislipidemy in T1DMMaterials and methods: Total 726 patients with T1DM (348m, 378f), mean age (M±σ) 34.71±0.58 yrs (1–78), age of T1DM manifestation 12.41±0.36 yrs and sp...